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Updated: Jun 4, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
Published on: June 6, 2011
[Frontiers of blood transfusion for critical bleeding: preface and comments]
1Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo 113-8421.
Insights
Massive bleeding causes critical intraoperative cardiac arrest. Guidelines were developed to improve blood transfusion practices and patient outcomes in critical bleeding cases.
Area of Science:
- Anesthesiology
- Transfusion Medicine
- Critical Care Medicine
Context:
- Annual surveys (1999-2002) in Japanese Society of Anesthesiologists (JSA)-certified hospitals identified massive bleeding as a primary cause of intraoperative cardiac arrest.
- These surveys indicated underutilization of type-specific and emergent O-type blood transfusions.
- Poor prognosis, including death and permanent brain damage, was associated with critical bleeding events.
Purpose:
- To address the underutilization of appropriate blood transfusions in critical bleeding situations.
- To reduce the incidence of intraoperative cardiac arrest and improve patient prognosis.
- To encourage the development of institutional emergency blood transfusion guidelines.
Summary:
- Guidelines for managing critical bleeding were published by the JSA and the Japan Society of Transfusion Medicine and Cell Therapy in 2007.
- Further guidelines for critical bleeding management in obstetrics were released by five academic societies in 2010.
- Hospitals are encouraged to create institutional guidelines based on these national recommendations.
Impact:
- Aims to decrease the occurrence of critical bleeding during surgery.
- Seeks to improve survival rates and neurological outcomes for patients experiencing severe hemorrhage.
- Promotes standardized and evidence-based transfusion protocols in critical care settings.
Abstract:
The annual surveys of critical incidents in Japanese Society of Anesthesiologists (JSA)-certified hospitals in 1999-2002 demonstrated that massive and critical bleeding was the major cause of intraoperative cardiac arrest leading to poor prognosis including death and permanent brain damage. The surveys also suggested that type-specific blood transfusion and emergent O-type blood transfusions were underutilized. Therefore, the JSA and the Japan Society of Transfusion Medicine and Cell Therapy publicized the guidelines for treatment of critical bleeding in 2007. Five academic societies publicized the guidelines for management of critical bleeding in obstetrics in 2010. Each hospital is expected to make institutional emergency blood transfusion guidelines on the basis of the above guidelines in order to decrease the incidence of critical bleeding and to improve the prognosis of the patients with critical bleeding.
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