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Related Experiment Video

Updated: Jun 4, 2026

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

[Albumin and artificial colloids for massive bleeding].

Takehiko Iijima¹

¹Department of Anesthesiology, Kyorin University, Faculty of Medicine, Mitaka 181-8611.

Masui. the Japanese Journal of Anesthesiology

|February 26, 2011

Summary

This summary is machine-generated.

Efficient volume restoration is crucial for massive bleeding. Early use of crystalloid with red cell concentrate (RCC), followed by artificial colloids or albumin in later stages, manages intravascular volume loss effectively.

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Last Updated: Jun 4, 2026

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

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Published on: November 3, 2023

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

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Massive Pontine Hemorrhage by Dual Injection of Autologous Blood

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Area of Science:

Emergency Medicine
Critical Care
Resuscitation Science

Background:

Massive bleeding necessitates rapid intravascular volume restoration.
Two distinct phases exist: uncontrolled and controlled bleeding.

Purpose of the Study:

To outline optimal volume management strategies for massive bleeding.
To discuss the roles of crystalloids, red cell concentrate (RCC), artificial colloids, and albumin.

Main Methods:

Review of fluid resuscitation principles in massive hemorrhage.
Analysis of fluid choices during uncontrolled and controlled bleeding phases.

Main Results:

Crystalloid and RCC are primary for initial uncontrolled bleeding to prevent shock.
Artificial colloids and RCC are preferred for controlled bleeding phase volume restoration.
Albumin may offer anti-inflammatory benefits and reduce edema; newer hydroxyethyl starch is a promising blood substitute.

Conclusions:

Phased volume management is essential for massive bleeding.
Careful selection of resuscitation fluids, including newer colloids, optimizes outcomes.
Purposeful use of volume expanders minimizes potential side effects.