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Comosusols A-D and comosone A: cytotoxic compounds from the brown alga Sporochnus comosus
Simon P B Ovenden1, Jonathan L Nielson, Catherine H Liptrot
1Australian Institute of Marine Science, PMB No. 3, Townsville MC, Townsville, 4810, Australia.
Abstract:
Bioassay-guided fractionation of extracts of the brown alga Sporochnus comosus led to the isolation of five new compounds, comosusols A-D (3-6) and comosone A (7). The structures of all isolated compounds were elucidated using standard one- and two-dimensional NMR techniques, as well as comparison with literature values. The cytotoxic activity of all compounds was investigated against a panel of human tumor and mammalian cell lines. These assays found eight of the nine compounds had GI(50) values in the 8-63 μM range.
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