Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Humoral Immune Responses01:36

Humoral Immune Responses

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16<sup>INK4A</sup> in Controlling TCR-Dependent and Independent CD8 T Cell Expansion.

European journal of immunology·2026
Same author

Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

TMPRSS2-mediated coronavirus spike activation and inhibition.

Nature structural & molecular biology·2026
Same author

Fc-engineered antibodies enhance protection against SARS-CoV-2 lung infection and inflammation.

mBio·2026
Same author

An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis.

Nature communications·2026
Same author

Potent efficacy of an NA-targeting antibody against a broad spectrum of H5N1 influenza viruses.

Nature communications·2026

Related Experiment Video

Updated: Jun 4, 2026

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
08:26

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

Dissecting the human immunologic memory for pathogens.

Christina E Zielinski1, Davide Corti, Federico Mele

  • 1Institute for Research in Biomedicine, Bellinzona, Switzerland.

Immunological Reviews
|February 26, 2011
PubMed
Summary

Understanding immunologic memory is key for vaccine development. This study explores the cellular basis of memory and introduces new high-throughput methods to analyze human immune cells for improved vaccine design.

More Related Videos

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

Related Experiment Videos

Last Updated: Jun 4, 2026

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
08:26

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

Area of Science:

  • Immunology
  • Vaccinology
  • Cellular Biology

Background:

  • Immunologic memory is crucial for effective vaccine development.
  • Understanding the cellular basis of human immunologic memory is essential for identifying protection correlates.
  • Existing methods may not fully capture the complexity of human memory immune cells.

Purpose of the Study:

  • To provide an overview of the cellular basis of immunologic memory.
  • To describe novel high-throughput experimental approaches for interrogating human memory T cells, B cells, and plasma cells.
  • To highlight the utility of these approaches in advancing vaccine design through 'analytic vaccinology'.

Main Methods:

  • Review of the cellular mechanisms underlying immunologic memory.
  • Development and description of high-throughput cell culture systems.
  • Interrogation of human memory T cells, B cells, and plasma cells using novel assays.

Main Results:

  • The study outlines the fundamental cellular components of immunologic memory.
  • Novel high-throughput methods enable detailed analysis of human memory immune cells.
  • These methods offer new insights into immune responses relevant to vaccination.

Conclusions:

  • The cellular basis of immunologic memory is well-defined but requires further human-specific investigation.
  • High-throughput cell culture techniques provide powerful tools for studying human memory cells.
  • The proposed 'analytic vaccinology' approach can significantly enhance vaccine design and development.