Related Experiment Video
Updated: Jun 4, 2026

A Murine Model of Vertical Sleeve Gastrectomy
Published on: December 18, 2017
Update: metabolic and cardiovascular consequences of bariatric surgery
Donald W Richardson1, Mary Elizabeth Mason, Aaron I Vinik
1Department of Medicine, L.R. Strelitz Diabetes Center for Endocrinology and Metabolism, L.R. Strelitz Diabetes Research Institute, Eastern Virginia Medical School, 855 West Brambleton Boulevard, Norfolk, VA 23510, USA. richardw@evms.edu
Abstract:
Obesity is a disease state with polygenic inheritance, the phenotypic penetrance of which has been greatly expanded by the attributes of modern civilization. More than two-thirds of obese persons have comorbidities, many of which are characteristic of cardiometabolic risk syndrome (CMRS) in addition to other life-quality-reducing complaints. The CMRS is associated with increased cardiovascular events and mortality. Individuals with a body mass index greater than 35 infrequently achieve or maintain weight loss adequate to resolve these metabolic and anatomic issues by lifestyle or pharmacologic strategies. Data suggest that some of these patients may be better served by bariatric surgery.
Related Concept Videos
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Metabolic States of the Body: The Postabsorptive State
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Obesity
Cardiomyopathy VII: Pre and Post Operative Nursing Management
Metabolic States of the Body: Fasting and Starvation
Type II Diabetes II: Pathophysiology

