Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

Diversity of Antigen Receptors

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An ancient evolutionary origin for IL-1 cytokines as mediators of immunity.

bioRxiv : the preprint server for biology·2025

Same author

The classical MHC class I and II genes of O. m. formosanus exhibit different polymorphism levels.

Developmental and comparative immunology·2025

Same author

Transient chromatin decompaction at the start of <i>D. melanogaster</i> male embryonic germline development.

Life science alliance·2024

Same author

The cytokine genes of Oncorhynchus masou formosanus include a defective interleukin-4/13A gene.

Developmental and comparative immunology·2024

Same author

Polystyrene-colonizing bacteria are enriched for long-chain alkane degradation pathways.

PloS one·2023

Same author

Functional characterization of the MyD88 homologs in Strongylocentrotus purpuratus.

Developmental and comparative immunology·2022

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches

Published on: June 25, 2020

RAG-2 unleashed: lymphocytes beware.

Sebastian D Fugmann¹

¹Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. fugmanns@grc.nia.nih.gov

|February 26, 2011

Summary

This summary is machine-generated.

The RAG-2 enzyme

More Related Videos

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

Related Experiment Videos

Last Updated: Jun 4, 2026

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches

Published on: June 25, 2020

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

Area of Science:

Immunology
Molecular Biology
Cell Cycle Regulation

Background:

V(D)J recombination is essential for adaptive immunity.
The RAG-2 enzyme's activity is cell cycle-dependent.
Aberrant V(D)J recombination can lead to genomic instability and cancer.

Discussion:

The programmed degradation of RAG-2 at S phase entry restricts V(D)J recombination to G0-G1.
This cell cycle regulation prevents the accumulation of DNA damage during replication.
Zhang et al. demonstrate the critical role of RAG-2 degradation in preventing lymphoma.

Key Insights:

RAG-2 degradation is a crucial checkpoint for V(D)J recombination.
Loss of this checkpoint leads to lymphoma formation.
Cell cycle control of V(D)J recombination is vital for preventing oncogenesis.

Outlook:

Further investigation into the regulatory mechanisms of RAG-2 degradation.
Exploring therapeutic strategies targeting RAG-2 regulation in lymphoma.
Understanding the broader implications of cell cycle control in DNA recombination processes.