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Updated: Jun 4, 2026

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

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Published on: March 30, 2020

Collagen containing microcapsules: smart containers for disease controlled therapy.

Laura Pastorino¹, Svetlana Erokhina, Federico Caneva Soumetz

¹Department of Communication, Computer and System Sciences, University of Genova, Via all'Opera Pia 13, 16145 Genova, Italy. laura.pastorino@unige.it

Journal of Colloid and Interface Science

|February 26, 2011

Summary

Researchers developed collagen-based microcapsules for drug delivery. These capsules release medication on demand, triggered by matrix metalloproteinases associated with pathological conditions.

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Area of Science:

Biomaterials Science
Drug Delivery Systems
Tissue Engineering

Background:

Collagen is a key connective tissue protein vital for biological functions.
Degradation of collagen is implicated in various pathological processes, often involving matrix metalloproteinases (MMPs).
Controlled drug release systems are needed to target pathological conditions effectively.

Purpose of the Study:

To fabricate collagen-based microcapsules for drug encapsulation.
To achieve drug release modulated by cellular demand via matrix metalloproteinase action.
To develop a responsive drug delivery system based on collagen and MMPs.

Main Methods:

Fabrication of collagen type I microcapsules using layer-by-layer assembly with poly(styrene sulfonate).
Characterization of shell growth using quartz crystal microbalance and X-ray reflectivity.
Morphological analysis via scanning electron microscopy and permeability studies using Confocal Laser Scanning Microscopy.
Investigation of matrix metalloproteinase 1 interaction with collagen films.

Main Results:

Successfully fabricated hollow collagen-based microcapsules.
Demonstrated matrix metalloproteinase 1 mediated changes in capsule permeability.
Confirmed the interaction between matrix metalloproteinase 1 and collagen films.
Visualized MMP-1 mediated drug release variations.

Conclusions:

Collagen-based microcapsules can be fabricated for controlled drug delivery.
Drug release can be engineered to be dependent on the pathological biochemical environment.
This system offers a potential strategy for demand-based drug release in disease states.