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Peptide Identification Using Tandem Mass Spectrometry

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...

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The ITS2 Database

The ITS2 Database

Published on: March 12, 2012

MPID-T2: a database for sequence-structure-function analyses of pMHC and TR/pMHC structures.

Javed Mohammed Khan¹, Harish Reddy Cheruku, Joo Chuan Tong

¹Department of Chemistry and Biomolecular Sciences and ARC Centre of Excellence in Bioinformatics, Macquarie University, Sydney, NSW, Australia.

Bioinformatics (Oxford, England)

|February 26, 2011

Summary

The MHC-Peptide Interaction Database-TR version 2 (MPID-T2) is a new resource for studying peptide-MHC (pMHC) and T-cell receptor (TR) interactions. It provides crucial sequence-structure-function data to understand molecular recognition mechanisms.

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A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Area of Science:

Immunology
Structural Biology
Bioinformatics

Background:

Understanding peptide-MHC (pMHC) and T-cell receptor (TR)/pMHC interactions is vital for molecular recognition mechanisms.
The MHC-Peptide Interaction Database-TR version 2 (MPID-T2) has been updated and enhanced.

Purpose of the Study:

To present the updated MHC-Peptide Interaction Database-TR version 2 (MPID-T2).
To provide advanced features and new parameters for analyzing pMHC and TR/pMHC structures.

Main Methods:

Augmented the database with the latest data from the Protein Data Bank (PDB) and IMGT/3Dstructure-DB.
Incorporated advanced features and new parameters for structural analysis.

Main Results:

MPID-T2 now offers comprehensive sequence-structure-function information on pMHC and TR/pMHC interactions.
The database facilitates detailed analysis of pMHC and TR/pMHC structures.

Conclusions:

MPID-T2 serves as a valuable resource for researchers studying adaptive immunity and molecular recognition.
The enhanced database supports deeper insights into the mechanisms of T-cell recognition of pMHC complexes.