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Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development
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FNV: light-weight flash-based network and pathway viewer.

Ruth Dannenfelser1, Alexander Lachmann, Mariola Szenk

  • 1Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY), Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.

Bioinformatics (Oxford, England)
|February 26, 2011
PubMed
Summary
This summary is machine-generated.

We developed a Flash-based network viewer (FNV) for visualizing biological networks and pathways. This tool enhances pathway visualization and integration into web systems and publications.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Systems Biology

Background:

  • Network diagrams are crucial for visualizing complex biological relationships, including genes, proteins, and metabolites.
  • Existing web-based pathway viewers have limitations, necessitating improved visualization tools.
  • The Flash-based Network Viewer (FNV) was developed to address these limitations for small to moderately sized biological networks.

Purpose of the Study:

  • To develop an improved, interactive network viewer for biological pathways.
  • To create a versatile tool for visualizing gene and protein interactions.
  • To facilitate the integration of pathway data into various web-based systems and publications.

Main Methods:

  • Developed a Flash-based network viewer (FNV) using Adobe ActionScript 3.0.
  • Implemented functionality to accept Extensible Markup Language (XML) formatted input files for pathway data.
  • Enabled vector graphics display with flexible layout options and user interactivity.

Main Results:

  • FNV provides interactive visualization of biological networks and pathways.
  • The viewer supports features like tooltips, hyperlinks, and node rearrangement.
  • FNV has been integrated into several established web-based systems, including Genes2Networks and KEA.

Conclusions:

  • FNV offers a flexible and interactive solution for visualizing biological pathways.
  • The tool enhances communication of pathway information in digital and soft publication formats.
  • FNV is available for download with documentation and sample networks.