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Updated: Jun 4, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation
Published on: December 5, 2025
Unusual applications of noninvasive ventilation
1Pulmonary and Respiratory Intensive Care Unit, Cardio-Thoracic Department, University Hospital Pisa, Pisa, Italy.
Noninvasive ventilation (NIV) is effective in many common respiratory conditions and is increasingly used in unusual situations. Careful patient selection and monitoring are crucial for optimizing NIV outcomes.
Area of Science:
- Pulmonology
- Critical Care Medicine
Background:
- Noninvasive ventilation (NIV) is widely used for acute hypercapnic respiratory failure, cardiogenic pulmonary edema, ARDS, pneumonia, and post-extubation failure.
- Its application in less common clinical scenarios is gaining attention.
Purpose of the Study:
- To review the evidence and clinical utility of NIV in unusual conditions.
- To highlight specific applications and contraindications for NIV.
Main Methods:
- Literature review of studies investigating NIV use in diverse clinical settings.
- Analysis of evidence supporting NIV in specific procedures and patient groups.
Main Results:
- NIV is supported during fiberoptic bronchoscopy, especially for high-risk patients.
- NIV can reduce sedation needs in procedures like transesophageal echocardiography and interventional cardiology/pulmonology.
- Evidence suggests NIV utility post-cardiac surgery and in pulmonary contusion, though with lower certainty.
- NIV is not a substitute for endotracheal intubation (ETI) in severe airborne infections progressing to ARDS.
- NIV is increasingly used for dyspnea relief in end-stage patients.
Conclusions:
- NIV has expanding applications beyond traditional uses, including procedural support and palliative care.
- Contraindications include severe airborne infections requiring ETI.
- Optimal outcomes with NIV depend on a skilled team, appropriate patient selection, and device choice.
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