Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

Acute Inflammation III: Local and Systemic Effects

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

Inflammatory Response I: Vascular and Cellular

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...

Acute Inflammation II: Cellular Phase

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...

Inflammation

Inflammation

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Decoding fibrosis in nonresolvable COVID-19: a role for myeloid-specific HIF1A deletion.

American journal of physiology. Cell physiology·2025

Same author

Enhancing Extracellular Adenosine Levels Restores Barrier Function in Acute Lung Injury Through Expression of Focal Adhesion Proteins.

Frontiers in molecular biosciences·2021

Same author

MicroRNA-98 reduces nerve growth factor expression in nicotine-induced airway remodeling.

The Journal of biological chemistry·2020

Same author

Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation.

The Journal of experimental medicine·2019

Same author

Transforming growth factor β1 alters the 3'-UTR of mRNA to promote lung fibrosis.

The Journal of biological chemistry·2019

Same author

Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines.

Genome medicine·2019

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

On-Chip Endothelial Inflammatory Phenotyping

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

P2Y6 and vascular inflammation.

Michael R Blackburn¹

¹University of Texas Medical School at Houston.

|February 26, 2011

Summary

This summary is machine-generated.

Inflammatory stimuli increase P2Y6 receptor expression on the vascular endothelium. This P2Y6 receptor enhances systemic inflammatory responses, contributing to disease progression.

More Related Videos

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice

Published on: August 13, 2015

Related Experiment Videos

Last Updated: Jun 4, 2026

On-Chip Endothelial Inflammatory Phenotyping

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice

Published on: August 13, 2015

Area of Science:

Immunology
Vascular Biology
Molecular Biology

Background:

Inflammation plays a critical role in numerous diseases.
The vascular endothelium is a key regulator of inflammatory processes.
Understanding molecular mechanisms of endothelial activation is crucial.

Discussion:

Riegel and colleagues identify the P2Y6 receptor as a key mediator.
The P2Y6 receptor is upregulated on vascular endothelium by inflammatory stimuli.
This upregulation potentiates systemic inflammatory responses.

Key Insights:

Demonstrates inflammatory stimuli induce P2Y6 receptor expression on vascular endothelium.
Highlights the role of P2Y6 receptor in enhancing systemic inflammation.
Provides a novel molecular target for inflammatory diseases.

Outlook:

Further research into P2Y6 receptor signaling pathways.
Therapeutic targeting of P2Y6 receptor for inflammatory conditions.
Investigating the role of P2Y6 in specific disease contexts.