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Increased thyroid function and elevated thyroid autoantibodies in pediatric patients with moyamoya disease: a
Hao Li1, Zheng-Shan Zhang, Zhen-Nan Dong
1Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.
Stroke
|February 26, 2011
Summary
Pediatric moyamoya disease is linked to increased thyroid function and elevated thyroid autoantibodies. Monitoring these thyroid markers may aid in managing the condition.
Area of Science:
- Endocrinology
- Neurology
- Pediatrics
Background:
- Moyamoya disease is a rare cerebrovascular disorder.
- The role of thyroid dysfunction in moyamoya disease is not well understood.
Purpose of the Study:
- To investigate the association between thyroid function, thyroid autoantibodies, and the risk of moyamoya disease in children.
Main Methods:
- Thyroid function tests and autoantibody levels were assessed in pediatric moyamoya disease patients and healthy controls.
- Multivariate analysis was used to determine the association with moyamoya disease risk.
Main Results:
- 114 pediatric patients and 114 controls were included.
- Increased thyroid function (OR 12.47) and elevated thyroid autoantibodies (OR 4.33) were significantly more prevalent in patients with moyamoya disease.
- These associations remained significant after multivariate adjustment.
Conclusions:
- Thyroid dysfunction and autoantibodies are associated with moyamoya disease in pediatric subjects.
- Monitoring thyroid function and autoantibodies in these patients is recommended for clinical management.
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