Related Experiment Video
Updated: Jun 4, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Increased thyroid function and elevated thyroid autoantibodies in pediatric patients with moyamoya disease: a
Hao Li1, Zheng-Shan Zhang, Zhen-Nan Dong
1Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China.
Background And Purpose:
The purpose of this study was to investigate whether thyroid function and thyroid autoantibodies were associated with the risk of moyamoya disease in pediatric subjects.
Methods:
Thyroid function and thyroid autoantibodies were evaluated in patients with moyamoya disease and control subjects, and their associations with moyamoya disease were estimated using multivariate analysis.
Results:
We included 114 pediatric patients and 114 healthy control subjects. The patients displayed higher prevalence of increased thyroid function and elevated thyroid autoantibodies in comparison with control subjects. These remained significant after multivariate adjustment; the ORs (95% CI) for increased thyroid function and evaluated thyroid autoantibodies were evaluated as 12.47 (1.55 to 100.51) and 4.33 (1.29 to 14.59), respectively.
Conclusions:
Increased thyroid function and elevated thyroid autoantibodies are associated with moyamoya disease and therefore monitoring of thyroid function and thyroid autoantibodies in patients with moyamoya disease is suggested, which might help to guide subsequent clinical management.
Related Concept Videos
Graves Disease II: Pathophysiology
Graves' Disease I: Introduction
Hyperthyroidism II: Pathophysiology
Hyperthyroidism I: Introduction
Hypothyroidism II: Pathophysiology
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
