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Published on: June 3, 2019
Relations of circulating resistin and adiponectin and cardiac structure and function: the Framingham Offspring Study
David D McManus1, Asya Lyass, Erik Ingelsson
1National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Insights
Higher levels of adiponectin and resistin are linked to reduced left ventricular mass and improved heart function, respectively. These adipocytokines may explain how obesity contributes to heart failure risk.
Area of Science:
- Cardiology
- Endocrinology
- Obesity Medicine
Background:
- Obesity is a known risk factor for pathological cardiac remodeling and heart failure (HF).
- Adipocytokines (ADKs) are signaling molecules from adipose tissue that may link obesity to cardiovascular disease.
- Limited data exist on the relationship between specific ADKs and cardiac remodeling phenotypes.
Purpose of the Study:
- To investigate the association between two key ADKs, adiponectin and resistin, and echocardiographic markers of cardiac remodeling.
- To examine the relationship between ADKs and left ventricular mass (LVM), left atrial diameter (LAD), and left ventricular fractional shortening (LVFS).
Main Methods:
- Analysis of 2,615 participants from the Framingham Offspring Study (mean age 61 years, 55% women).
- Measurement of circulating adiponectin and resistin concentrations.
- Assessment of LVM, LAD, and LVFS using echocardiography.
- Multivariable linear regression models were used, adjusting for clinical correlates including body mass index (BMI).
Main Results:
- Adiponectin concentrations were inversely associated with LVM (P = 0.02).
- Resistin concentrations were inversely associated with LVFS (P = 0.03).
- No significant associations were found between adiponectin and LAD/LVFS, or between resistin and LVM/LAD.
Conclusions:
- Higher circulating adiponectin is associated with lower left ventricular mass.
- Higher circulating resistin is associated with lower left ventricular fractional shortening.
- These findings suggest potential mechanisms by which adiposity influences cardiac remodeling and heart failure risk.
Abstract:
Obesity is associated with pathological cardiac remodeling and risk of heart failure (HF). Adipocytokines (ADKs) may mediate the increased risk of cardiovascular disease associated with excess adiposity. Yet data relating ADKs to cardiac remodeling phenotypes are sparse. We related two circulating ADKs, resistin and adiponectin, to three important echocardiographic markers of cardiac remodeling, left ventricular mass (LVM), left atrial diameter (LAD), and LV fractional shortening (LVFS) in 2,615 participants (mean age 61 years, 55% women) in the Framingham Offspring Study. Adiponectin concentrations were inversely related to LVM in multivariable linear regression models adjusting for key clinical correlates including BMI (regression coefficient per s.d.-increment in ln-adiponectin = -3.37, P = 0.02; P for trend across quartiles = 0.02). Adiponectin was not associated with LAD or LVFS (P > 0.56). Resistin concentrations were inversely related to LVFS (regression coefficient per s.d.-increment in ln-resistin = -0.01, P = 0.03; P for trend across quartiles = 0.04). Resistin was not associated with LVM or LAD (P > 0.05). In our moderate-sized, community-based sample, higher circulating concentrations of adiponectin and resistin were associated with lower LVM and lower LVFS, respectively. In conclusion, these associations identify potential mechanisms by which excess adiposity may mediate adverse cardiac remodeling and HF risk.
