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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

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Published on: May 2, 2013

[Transplant-associated lymphoproliferation].

K Hussein¹, B Maecker-Kolhoff, C Klein

¹Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

|February 26, 2011

Summary

This summary is machine-generated.

Immunosuppressive drugs after organ or stem cell transplants can increase the risk of Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD). Reducing immunosuppression can sometimes resolve PTLD, even in severe cases.

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Area of Science:

Immunology
Oncology
Virology

Context:

Solid organ and hematopoietic stem cell transplantation necessitate immunosuppressive therapy to prevent rejection and graft-versus-host disease.
Immunosuppression regimens are associated with an increased risk of Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD).

Purpose:

To delineate the spectrum of Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD) lesions.
To characterize the different classifications of PTLD, including hyperplastic, polymorphic, and monomorphic types.
To investigate the therapeutic potential of reducing immunosuppression in managing PTLD.

Summary:

PTLD encompasses a range of lesions from hyperplastic to overt lymphomas, classified as monomorphic PTLD.
Hyperplastic lesions present as early or mononucleosis-like changes, while polymorphic PTLD features effaced lymph node architecture or extranodal involvement.
Monomorphic PTLD typically involves high-grade B-cell lymphomas, plasma cell neoplasms, or Hodgkin lymphomas, rarely T-cell lymphomas; low-grade B-cell lymphomas are not observed.

Impact:

Understanding PTLD lesion spectrum aids in accurate diagnosis and risk stratification.
Identifying PTLD subtypes is crucial for guiding treatment strategies.
Demonstrates that reducing immunosuppression can be a viable therapeutic option for PTLD, potentially inducing remission in a subset of patients.