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Updated: Jun 4, 2026

Intracameral Injection in Rats with Low Risk of Adverse Effects
Published on: May 31, 2024
[Janus-faced?: Effects and side-effects of interferon therapy in ophthalmology]
N Stübiger1, S Winterhalter, U Pleyer
1Augenklinik, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Deutschland. nicole.stuebiger@charite.de
Abstract:
Interferon alpha (IFN-α) and interferon beta (IFN-β) are naturally occurring cytokines, which belong to the type I interferons and share the same receptor leading to very similar therapeutic effects. The immunomodulatory effect of type I interferons includes modulation of antibody production, inhibition of lymphocyte proliferation, inhibition of delayed-type hypersensitivity and enhancement of T-cell and NK-cell cytotoxicity. An increasing number of open clinical studies and case reports have demonstrated the efficacy of IFN-α for severe ocular inflammation in patients with Behçet's disease and of interferon-β, which has been used mainly for the treatment of multiple sclerosis.
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