[A new cyanosides from Rhodiola bupleuroldes]

Area of Science:

• Phytochemistry
• Natural Product Chemistry
• Pharmacognosy

Background:

• Rhodiola species are known for their medicinal properties.
• The chemical constituents of Rhodiola bupleuroides are not fully elucidated.
• Ethnobotanical uses suggest potential for novel bioactive compounds.

Purpose of the Study:

• To isolate and characterize chemical compounds from the 70% ethanol extract of Rhodiola bupleuroides stems.
• To identify known and potentially novel natural products from this plant species.
• To contribute to the phytochemical understanding of the Rhodiola genus.

Main Methods:

• Extraction of plant material using 70% ethanol.
• Isolation of compounds via repeated silica gel column chromatography.
• Structure elucidation using spectroscopic techniques (UV, IR, ESI-MS, 1H NMR, 13C NMR, 2D NMR) and chemical methods.

Main Results:

• Five compounds were successfully isolated and identified.
• Rhobupcyanoside A (1) was identified as a new compound.
• p-Coumaric acid (2), 4,5-dihydroxy-3-methoxybenzoic acid (3), schizandriside (4), and kaempferol (5) were isolated from R. bupleuroides for the first time.

Conclusions:

• The phytochemical investigation of Rhodiola bupleuroides yielded five compounds, including one novel entity.
• This study expands the knowledge of the chemical diversity within the Rhodiola genus.
• The identified compounds may serve as a basis for future pharmacological studies.