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Updated: Jun 4, 2026

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice
Published on: January 19, 2018
[Advances in the study of the anti-tumor activity of small molecule vascular disrupting agents]
Yu-chen Cai1, Yong Zou, Li-jian Xian
1State Key Laboratory of Oncology in South China, Guangzhou 510060, China.
Abstract:
Vascular disrupting agents (VDAs) have presented a new kind of anti-cancer drug in recent years. VDAs take advantage of the weakness of established tumor endothelial cells and their supporting structures. In contrast to anti-angiogenic therapy, which inhibits the outgrowth of new blood vessels, vascular targeting treatments selectively attack the existing tumor vasculature. Here we summarized the anti-tumor activities, mechanisms and clinical applications of small molecule VDAs.
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