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Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
Published on: January 15, 2018
[Preparation of polyelectrolyte microcapsules contained gold nanoparticles]
Ya-jie Sun1, Jia-bi Zhu, Chun-li Zheng
1Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210009, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|March 1, 2011
Summary
Researchers developed polyelectrolyte microcapsules with gold nanoparticles for drug delivery. These microcapsules demonstrated efficient loading and encapsulation of FITC-bovine serum albumin, showing potential for biomedical applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Polyelectrolyte microcapsules offer versatile platforms for drug delivery.
- Gold nanoparticles can enhance the properties of microcapsule systems.
- Controlled synthesis is crucial for effective drug encapsulation and release.
Purpose of the Study:
- To synthesize polyelectrolyte microcapsules incorporating gold nanoparticles.
- To evaluate the encapsulation efficiency and drug loading capacity of the developed microcapsules.
- To characterize the morphology and properties of the synthesized microcapsules.
Main Methods:
- Layer-by-layer assembly was used to create polyelectrolyte shells on CaCO3 microparticles.
- Gold nanoparticles and poly(allylamine hydrochloride) (PAH) were utilized in the coating process.
- Scanning electron microscopy (SEM) and fluorescence microscopy were employed for characterization and quantification.
Main Results:
- Successfully prepared polyelectrolyte microcapsules with embedded gold nanoparticles.
- Achieved an encapsulation efficiency of (34.31 ± 2.44)% for FITC-bovine serum albumin (FITC-BSA).
- Obtained a drug loading of (43.75 ± 3.12) mg g(-1) of FITC-BSA.
Conclusions:
- The layer-by-layer assembly method is effective for creating gold nanoparticle-loaded polyelectrolyte microcapsules.
- The developed microcapsules show promising potential for drug delivery applications due to their loading and encapsulation capabilities.
- Further studies can explore controlled release mechanisms and in vivo performance.
