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Updated: Jun 4, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014
[Research progress of C terminal propeptide of collagen type II]
1Department of Orthopedics, Shengjing Hospital, China Medical University, Shenyang Liaoning, 110001, P.R. China. bailh@cmu2h.com
Objective:
To review the research progress of C terminal propeptide of collagen type II (CTX-II), a osteoarthritis (OA) biomarker.
Methods:
Domestic and international literature about CTX-II was reviewed extensively and summarized.
Results:
CTX-II is investigated broadly and has the best performance of all currently available biomarkers. CTX-II is a truly useful biomarker for early diagnosis, prognosis, and measurement of treatment response in OA.
Conclusion:
Single CTX-II may be not sufficient for early diagnosis and prognosis of OA, so a combination of CTX-II and other biomarkers or diagnosis methods is needed.
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