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Updated: Jun 4, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
[Expression changes of glutathione transferase omega 1 induced by low dose trichloroethylene]
Haiyan Huang1, Zhixiong Zhuang, Jianjun Liu
1Toxicology Laboratory, Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, China. hhy424@126.com
Objective:
To determine the expression of glutathione transferase omega 1 (GSTO-1) during hormesis induced by low dose trichloroethylene (TCE).
Methods:
Based on the dose-response of hormesis induced by TCE, the total protein and mRNA from four groups was extracted, and expression of GSTO-1 was detected by western blotting and RT-PCR technology.
Results:
The study showed that increases of GSTO-1 protein expression were induced by TCE at low dose (0.1 mmol/L) TCE, but there was no significant different between the high-dose group and the control (P < 0.05). RT-PCR analysis presented the expression of GSTO-1 gene in low-dose group was increased, but the opposite effect was observed in the high-dose group.
Conclusion:
GSTO-1 may be play a key role in hormesis induced by TCE.
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