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Comparative effectiveness research: guidelines for good practices are just the beginning.

Michael L Johnson1, Abhishek S Chitnis

  • 1University of Houston, College of Pharmacy, 1441 Moursund Street, Houston, TX 77030, USA. mikejohnson@uh.edu

Expert Review of Pharmacoeconomics & Outcomes Research
|March 1, 2011
PubMed
Summary

The International Society for Pharmacoeconomics and Outcomes Research developed guidelines for comparative effectiveness research using large databases. This article reviews the task force, its report, and the future of this research area.

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Area of Science:

  • Health economics and outcomes research
  • Comparative effectiveness research

Background:

  • The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) established a task force to address the need for standardized practices in comparative effectiveness research (CER).
  • CER utilizes retrospective databases to evaluate treatment effects, but requires rigorous methodologies for reliable results.

Purpose of the Study:

  • To review the structure, process, and outcomes of the ISPOR task force on good research practices for CER.
  • To assess the impact of the task force's report on the field of CER.
  • To provide insights into the future direction of CER.

Main Methods:

  • The article examines the ISPOR task force, which convened experts to develop recommendations.
  • The task force's report, published in Value in Health, covered study design, data analysis, research question framing, and interpretation of findings from nonrandomized studies.
  • This article provides a commentary on the task force's work and its implications.

Main Results:

  • The ISPOR task force produced a comprehensive report offering state-of-the-art recommendations for CER using retrospective databases.
  • The report addressed critical aspects of CER, including design, analysis, and reporting of nonrandomized studies.
  • The task force's work aims to enhance the quality and reliability of CER.

Conclusions:

  • The ISPOR task force's report provides essential guidance for conducting robust comparative effectiveness research.
  • The recommendations are expected to improve the quality of evidence derived from retrospective databases.
  • The article suggests that this work will significantly influence the future of comparative effectiveness research and outcomes research.