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Encoding dysfunctions in a dynamic-static paradigm for visuospatial working memory in first-episode psychosis
Luca Cocchi1, Martin Debbané, Pascal Vianin
1Institute of Sport Science and Physical Education, Department of Physiology, Lausanne University, Lausanne, Switzerland. lcocchi@unimelb.edu.au
Early Intervention in Psychiatry
|March 1, 2011
Summary
First-episode psychosis patients exhibit significant visuospatial working memory (VSWM) deficits, particularly in dynamic tasks. Impaired dynamic VSWM at baseline may predict schizophrenia development.
Area of Science:
- Cognitive Neuroscience
- Psychiatry
- Neuroimaging
Background:
- First-episode psychosis (FEP) is a critical stage for understanding schizophrenia.
- Visuospatial working memory (VSWM) is frequently impaired in psychosis.
Purpose of the Study:
- To investigate static and dynamic VSWM in FEP patients.
- To assess VSWM as a potential trait marker for schizophrenia.
Main Methods:
- Twenty FEP patients and 20 matched controls completed static and dynamic VSWM tasks.
- Patients were followed for two years to diagnose psychiatric outcomes.
Main Results:
- FEP patients showed significant deficits in dynamic VSWM compared to controls.
- Poorer baseline dynamic VSWM scores predicted the development of schizophrenia at follow-up.
Conclusions:
- FEP is associated with VSWM deficits, especially in dynamic tasks.
- Impaired dynamic VSWM may serve as a reliable marker for schizophrenia.
