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Cardiac arrhythmia induced by interferon beta-1a

Sarrah Kastalli1, Sihem El Aïdli, Sami Mourali

  • 1Service de recueil et analyse des effets indésirables, Centre National de Pharmacovigilance, 9 Av Dr Zouheir Essafi 1006 Tunis, Tunisia.

Fundamental & Clinical Pharmacology
|March 1, 2011
PubMed

Cardiac adverse effects have never been reported with interferon (INF) beta. We report a case of left bundle branch block in a 35-year-old woman treated with INF beta-1a for multiple sclerosis. Five years after INF therapy, she presented loss of consciousness, retrosternal pains, short breath and lowered tolerance of effort. ECG and Holter 24-h ECG monitoring revealed permanent complete left bundle branch block. Nine months after stopping INF, no abnormalities were found at ECG and echocardiogram examination.

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