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Published on: August 31, 2015
Primary and secondary oxidative stress in Bacillus
1Laboratory of Food Microbiology, Wageningen University, Wageningen, The Netherlands. j.m.mols@rug.nl
Environmental Microbiology
|March 1, 2011
Summary
Bacillus species cope with oxidative stress from reactive oxygen species (ROS) and environmental factors. Understanding these responses aids in controlling spoilage and pathogenic bacteria.
Area of Science:
- Microbiology
- Molecular Biology
- Biochemistry
Background:
- Aerobic bacteria like Bacillus spp. must manage oxidative stress from reactive oxygen species (ROS) and environmental challenges.
- Oxidative stress is linked to exposure to oxidizing compounds, antibiotics, heat, and acid.
Purpose of the Study:
- To review novel insights into primary and secondary oxidative stress responses in Bacillus species.
- To compile knowledge on pathways and damaging radicals involved in oxidative stress.
Main Methods:
- Transcriptome studies
- Network analyses
- Single-cell fluorescence techniques for ROS detection
Main Results:
- Detailed insights into primary oxidative stress responses to hydrogen peroxide.
- Elucidation of secondary oxidative stress responses to various environmental stresses.
- Identification of involved pathways and damaging radicals.
Conclusions:
- Knowledge of Bacillus oxidative stress mechanisms is crucial for controlling spoilage and pathogenic bacteria.
- Exploiting this knowledge can lead to novel strategies for bacterial control.
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