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Updated: Jun 4, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Oncogene interactions are required for glioma development and progression as revealed by a tissue specific transgenic

Lynette M Moore1, Kristen M Holmes, Gregory N Fuller

  • 1Department of Pathology, the University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Chinese Journal of Cancer
|March 1, 2011
PubMed

Insights

Brain tumors are aggressive, developing drug resistance by circumventing targeted therapies. The RCAS/tv-a mouse model aids in understanding oncogene cooperation for developing more effective brain tumor treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Brain tumors exhibit aggressive and invasive characteristics, posing significant challenges for effective therapy development.
  • Drug resistance is a major hurdle, as brain tumors can circumvent targeted pathways.
  • Targeting multiple signaling pathways or nodes is a promising strategy for overcoming resistance.

Purpose of the Study:

  • To review the utility of the RCAS/tv-a mouse model in studying brain tumors.
  • To elucidate the role of oncogene cooperation in brain tumor development and progression.
  • To identify driver and passenger molecules for targeted therapy development.

Main Methods:

  • Focus on the RCAS/tv-a mouse model for brain tumor research.
  • Utilizing animal models to dissect tumorigenesis pathways.
  • Preclinical testing of therapeutic strategies in relevant models.

Main Results:

  • The RCAS/tv-a model offers unique insights into oncogene cooperation.
  • This model facilitates the dissection of critical components in tumor development.
  • It serves as a platform for preclinical evaluation of novel therapeutic approaches.

Conclusions:

  • The RCAS/tv-a mouse model is a valuable tool for brain tumor research.
  • Understanding oncogene cooperation is crucial for designing effective therapies.
  • Further research using this model can accelerate the development of treatments for aggressive brain tumors.

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