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Assessment of atrial conduction time in patients with essential hypertension
Mehmet Yunus Emiroglu1, Mustafa Bulut, Müslim Sahin
1Department of Cardiology, Kartal Kosuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey. yunusemiroglu@hotmail.com
Insights
Essential hypertension is linked to prolonged atrial conduction times, specifically interatrial electromechanical delay and P-wave dispersion. These findings may explain the higher incidence of atrial fibrillation in hypertensive patients.
Area of Science:
- Cardiology
- Electrophysiology
- Hypertension Research
Background:
- Essential hypertension is a significant risk factor for cardiovascular complications.
- Atrial conduction abnormalities are increasingly recognized in hypertensive individuals.
Purpose of the Study:
- To evaluate atrial conduction parameters in patients diagnosed with essential hypertension.
- To investigate the relationship between hypertension and atrial electromechanical delay and P-wave dispersion.
Main Methods:
- A cohort of 80 hypertensive patients and 80 controls underwent assessment.
- Key measurements included atrial electromechanical coupling (PA), intra- and interatrial electromechanical delay (AEMD), and P-wave dispersion (Pd).
- Tissue Doppler echocardiography and surface electrocardiogram (ECG) were utilized for measurements.
Main Results:
- Hypertensive patients exhibited significantly longer atrial electromechanical coupling durations at both septal and lateral mitral annuli compared to controls.
- Interatrial and intraatrial electromechanical delays were markedly prolonged in the hypertension group.
- Maximum P-wave duration and P-wave dispersion were significantly higher in patients with hypertension.
Conclusions:
- Prolonged interatrial electromechanical delay and P-wave dispersion are evident in patients with essential hypertension.
- A significant correlation was observed between interatrial electromechanical delay and P-wave dispersion.
- These prolonged conduction times may contribute to the elevated risk of atrial fibrillation in hypertensive individuals, warranting further prospective investigation.
Background:
We aimed to assess atrial conduction time in patients with essential hypertension.
Methods:
A total of 80 patients with hypertension (51 males/29 females, 53 ± 12.5 years) and 80 controls (50 males/30 females, 50 ± 12 years) were included. Atrial electromechanical coupling (time interval from the onset of P wave on surface electrocardiogram [ECG] to the beginning of A wave interval with tissue Doppler echocardiography [PA]), intraatrial and interatrial electromechanical delay (intra and inter atrial electromechanical delay [AEMD]), and P-wave dispersion (Pd) were measured (Appelton, C.P., Hatle, L., Popp, R.L., Relation of transmitral flow velocity patterns to left ventricular diastolic function: new insights from combined hemodynamic and Doppler echocardiographic study. J Am Coll Cardiol. 1988; 12: 426-440).
Results:
Atrial electromechanical coupling at the left lateral mitral annulus (PA lateral) and septal mitral annulus were longer in patients with hypertension (63.0 ± 8.0 vs 50.2 ± 4.3, P < .001, and 53.3 ± 6.2 vs 40.1 ± 5.5, P < .001). Interatrial (PA lateral-PA tricuspid) and intraatrial electromechanical delay (PA septum-PA tricuspid) were longer in patients with hypertension (24.8 ± 7.2 vs 12.4 ± 4.3, P < .001, and 14.1 ± 4.5 vs 2.3 ± 1.6, P < .001, respectively). Maximum P-wave duration and Pd were higher in patients with hypertension compared with controls (95.6 ± 8.0 vs 90.1 ± 9.5, P = .01, and 41.3 ± 7.1 vs 33.5 ± 6.1 P < .001, respectively). In correlation analysis, a positive correlation was detected between interatrial electromechanical delay and Pd (r = 0.72, P < .001). There was a moderate correlation between left ventricular mass index and PA lateral (r = 0.48, P < .001).
Conclusion:
Our results revealed that interatrial electromechanical delay and Pd were prolonged in patients with hypertension. Our results also showed a correlation between interatrial electromechanical delay and Pd. Prolonged electromechanical delay and Pd found in hypertensive patients could be related with increased incidence of atrial fibrillation in these patients. Prospective studies are needed to document the association between intraatrial and interatrial electromechanical delays and the development of atrial fibrillation.
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