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Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

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Published on: March 28, 2025

Antipsychotic sensitivity in normal pressure hydrocephalus.

Biswa Ranjan Mishra¹, Sukanto Sarkar, Sayali Mishra

¹Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand 834006, India. brm1678@rediffmail.com

General Hospital Psychiatry

|March 1, 2011

Summary

Normal pressure hydrocephalus can mimic psychiatric disorders. A patient with schizophrenia and antipsychotic intolerance was found to have communicating hydrocephalus, highlighting a crucial diagnostic link.

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Area of Science:

Neurology
Psychiatry

Background:

Normal pressure hydrocephalus (NPH) presents with a triad of gait disturbance, dementia, and urinary incontinence.
NPH symptoms can overlap with various psychiatric conditions, including psychosis and mood disorders.

Observation:

A patient diagnosed with schizophrenia exhibited severe intolerance to low-dose antipsychotic medications.
This patient's psychiatric symptoms were refractory to standard treatment approaches.

Findings:

Diagnostic investigation revealed the patient had undiagnosed communicating hydrocephalus.
Surgical or medical management of hydrocephalus may be indicated in patients with unexplained neurological and psychiatric symptoms.

Implications:

This case underscores the importance of considering NPH in patients with atypical or treatment-resistant psychiatric presentations.
Early diagnosis and management of hydrocephalus can potentially alleviate both neurological and psychiatric symptoms.