Related Experiment Video
Updated: Jun 4, 2026
08:10
A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits
Published on: November 24, 2015
Psychogenic polydipsia in bipolar affective disorder--a case report
Karthik Duraiswamy1, Naren P Rao, Ganesan Venkatasubramanian
1Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore-560029, India.
General Hospital Psychiatry
|March 1, 2011
Summary
Polydipsia, excessive thirst, is common in psychiatric patients but rarely noted in bipolar affective disorder (BPAD). Successful treatment of BPAD with polydipsia was achieved using valproate and risperidone.
Area of Science:
- Psychiatry
- Endocrinology
Background:
- Polydipsia, or excessive thirst, is a recognized but understudied symptom in psychiatric populations.
- While commonly associated with schizophrenia, polydipsia is infrequently reported in patients with bipolar affective disorder (BPAD).
Observation:
- This case report details a patient diagnosed with bipolar affective disorder (BPAD) who also presented with polydipsia.
- The presence of polydipsia in BPAD necessitates careful consideration due to potential complications and treatment challenges.
Findings:
- The study highlights the successful management of a patient with co-occurring BPAD and polydipsia.
- Treatment involved a combination therapy of valproate and risperidone, demonstrating efficacy in addressing both conditions.
Implications:
- Recognizing and treating polydipsia in BPAD is crucial for patient well-being and preventing serious health issues.
- The findings suggest that a combined approach with valproate and risperidone may be a viable therapeutic strategy for BPAD patients experiencing polydipsia.
Related Concept Videos
01:30Bipolar Disorder
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
01:29Diabetes Insipidus I: Introduction
Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...
01:22Diabetes Insipidus II: Pathophysiology
Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
01:19Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
01:25Borderline Personality Disorder
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Genetic and Environmental Contributions
Borderline Personality...
01:24Mania and Antimanic Drugs: Overview
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...