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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

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Related Experiment Video

Updated: Jun 4, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

MicroRNAs in pregnancy.

Diana M Morales Prieto1, Udo R Markert

  • 1Klinik für Frauenheilkunde und Geburtshilfe, Abteilung für Geburtshilfe, Placenta-Labor, Friedrich-Schiller-Universität Jena, Bachstr. 18, 07743 Jena, Germany.

Journal of Reproductive Immunology
|March 1, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene expression and are implicated in diseases. This review explores miRNA roles in pregnancy, suggesting maternal circulation miRNAs could diagnose pregnancy disorders.

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Last Updated: Jun 4, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

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Published on: June 24, 2020

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Area of Science:

  • Molecular Biology
  • Genetics
  • Reproductive Biology

Background:

  • Non-coding RNAs, including microRNAs (miRNAs), are key gene regulators.
  • MiRNAs control approximately 30% of human genes and are linked to diseases.
  • MiRNA involvement in pregnancy and placental development is under-investigated.

Purpose of the Study:

  • To review current knowledge on microRNA profiles and functions during pregnancy.
  • To examine miRNA roles in early development, placentation, and pregnancy pathologies.
  • To assess the diagnostic potential of circulating miRNAs for pregnancy disorders.

Main Methods:

  • Literature review of studies on microRNAs in pregnancy.
  • Analysis of miRNA expression and function in peri-implantation, embryonic stem cells, and placentation.
  • Investigation of miRNA involvement in pregnancy-related pathologies.

Main Results:

  • MicroRNAs play significant roles in placental development and pregnancy.
  • Dysregulation of miRNAs is associated with pregnancy complications.
  • Specific miRNA profiles are observed in various pregnancy disorders.

Conclusions:

  • MicroRNAs are crucial regulators throughout pregnancy.
  • Maternal circulating miRNAs show promise as biomarkers for diagnosing pregnancy disorders.
  • Further research into miRNA-mediated regulation in pregnancy is warranted.