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Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin

Birgit Obermeier1, Laura Lovato, Reinhard Mentele

  • 1Institute of Clinical Neuroimmunology, Ludwig Maximilians University, 81377 Munich, Germany.

Journal of Neuroimmunology
|March 1, 2011
PubMed

We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF.

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