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Related Experiment Videos

A second brain tumour and irradiation.

R G Robinson

    Journal of Neurology, Neurosurgery, and Psychiatry
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    High-dose radiation therapy for primary brain tumors may increase the risk of developing secondary brain tumors, including meningiomas and astrocytomas, years later. However, the oncogenic risks of radiotherapy do not outweigh its therapeutic benefits for brain tumors.

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    Area of Science:

    • Neuro-oncology
    • Radiation Oncology
    • Cancer Epidemiology

    Background:

    • Radiotherapy is a cornerstone in treating primary brain tumors.
    • Long-term effects of therapeutic radiation doses on secondary brain tumor development require ongoing investigation.
    • Previous studies suggest a link between ionizing radiation and meningioma risk.

    Observation:

    • Three patients developed secondary brain tumors (one meningioma, two cerebral astrocytomas) over 21 years after receiving ≥2750 rad for primary brain tumors.
    • Evidence supports an association between moderate ionizing radiation doses (e.g., for tinea capitis) and late-onset meningiomas.
    • Higher radiation doses for childhood tumors also correlate with an increased risk of meningioma.

    Findings:

    • Ionizing radiation exposure, particularly at higher doses for primary brain tumors, may be implicated in the late development of secondary meningiomas and astrocytomas.

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  • Current evidence is insufficient to establish a causal link between ionizing radiation and the etiology of gliomas.
  • The study highlights the potential for secondary malignancies following brain radiotherapy.

    • Implications:

    • While radiotherapy for brain tumors carries a risk of secondary malignancies, its therapeutic value is considered to outweigh these oncogenic hazards.
    • Further research is warranted to fully elucidate the relationship between radiation dose, fractionation, and the risk of specific secondary brain tumor types.
    • This underscores the importance of long-term patient surveillance for secondary cancers after radiotherapy.