Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Two-Dimensional (2D) NMR: Overview01:12

Two-Dimensional (2D) NMR: Overview

The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Micro RNA Sequencing in Circulating Tumor Cells.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

A noise-robust post-processing pipeline for accelerated phase-cycled <sup>23</sup>Na Multi-Quantum Coherences MRI.

Zeitschrift fur medizinische Physik·2025
Same author

Feasibility of relaxation along a fictitious field in the 2nd rotating frame (T<sub>RAFF2</sub>) mapping in the human myocardium at 3 T.

Frontiers in cardiovascular medicine·2024
Same author

Dormancy-inducing 3D engineered matrix uncovers mechanosensitive and drug-protective FHL2-p21 signaling axis.

Science advances·2024
Same author

Erratum to "Volumetric <sup>23</sup>Na single and triple-quantum imaging at 7T: 3D-CRISTINA" [Z Med Phys 32 (2022) 199-208].

Zeitschrift fur medizinische Physik·2024
Same author

Temporal and Spatial Dynamics of Ischemic Stroke Lesions after Acute Therapy: A Comprehensive Edema Assessment Using Combined 1H- and 23Na-MRI.

Cerebrovascular diseases (Basel, Switzerland)·2024

Related Experiment Video

Updated: Jun 4, 2026

Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration
05:30

Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration

Published on: May 19, 2023

Single-slice mapping of ultrashort T(2).

Stefan Kirsch1, Lothar R Schad

  • 1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany. stefan.kirsch@medma.uni-heidelberg.de

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|March 1, 2011
PubMed
Summary

This study introduces a new method for mapping ultrashort transverse relaxation times (T2) using a specialized Magnetic Resonance Imaging (MRI) pulse sequence. The technique accurately measures T2 values in materials and biological tissues, enabling new insights into their properties.

More Related Videos

Rapid Setup of Tissue Microarray and Tiled Area Imaging on the Multiplexed Ion Beam Imaging Microscope Using the Tile/SED/Array Interface
06:15

Rapid Setup of Tissue Microarray and Tiled Area Imaging on the Multiplexed Ion Beam Imaging Microscope Using the Tile/SED/Array Interface

Published on: September 15, 2023

Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy
09:24

Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy

Published on: January 30, 2020

Related Experiment Videos

Last Updated: Jun 4, 2026

Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration
05:30

Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration

Published on: May 19, 2023

Rapid Setup of Tissue Microarray and Tiled Area Imaging on the Multiplexed Ion Beam Imaging Microscope Using the Tile/SED/Array Interface
06:15

Rapid Setup of Tissue Microarray and Tiled Area Imaging on the Multiplexed Ion Beam Imaging Microscope Using the Tile/SED/Array Interface

Published on: September 15, 2023

Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy
09:24

Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy

Published on: January 30, 2020

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biophysics
  • Materials Science

Background:

  • Accurate measurement of ultrashort transverse relaxation times (T2) is crucial for understanding material properties and biological tissue characteristics.
  • Existing MRI methods often struggle to precisely quantify very short T2 values, limiting their application in specific research areas.
  • Developing advanced MRI techniques is essential for probing rapidly decaying signals in biological tissues and materials.

Purpose of the Study:

  • To present and validate a novel single-slice mapping method for ultrashort transverse relaxation times (T2).
  • To demonstrate the method's capability in accurately measuring T2 values in various phantoms and its potential for biological tissues.
  • To enable T2 mapping down to the microsecond range, expanding the scope of MRI applications.

Main Methods:

  • Implementation of a specialized RF pulse sequence involving spin echo preparation and slice-selective ultrashort echo time (UTE) imaging with radial k-space sampling.
  • Utilization of a slice-selective 180° RF refocusing pulse and a 4-step phase cycle to minimize echo time and signal contamination.
  • Testing the method on a phantom composed of adhesive tape, eraser, Plasticine®, and agar gel, with results compared to non-selective T2 measurements.

Main Results:

  • The method successfully measured T2 values in phantom samples, including adhesive tape (0.5 ± 0.1 ms), eraser (2.33 ± 0.07 ms), Plasticine® (2.8 ± 0.06 ms), and 10% agar (9.5 ± 0.83 ms).
  • Obtained T2 mapping values showed good agreement with non-selective T2 measurements.
  • Effective transverse relaxation time T2(*) was found to be significantly shorter than T2 for most samples, indicating rapid signal decay.

Conclusions:

  • The presented single-slice T2 mapping method is effective for accurately quantifying ultrashort transverse relaxation times.
  • The technique is suitable for investigating materials with short T2 values and has potential applications in studying biological tissues like bone, cartilage, and tendon.
  • The method can also be applied to analyze signals from quadrupolar nuclei, broadening its utility in diverse scientific research.