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Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
A novel colonoscope with high color-rendering white light-emitting diodes
Jun Nishikawa1, Hideo Yanai, Takeshi Okamoto
1Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Background:
Light-emitting diodes (LEDs) are being used for a variety of new uses because of their cost-effectiveness and durability. We therefore considered using white LEDs as a light source for GI endoscopes to simplify the endoscopic system.
Objective:
To assess the feasibility and safety of an LED-illuminated colonoscope.
Design:
Pilot study of the LED colonoscope in healthy human volunteers and patients with colorectal lesions.
Setting:
Yamaguchi University Hospital, Ube, Japan.
Interventions:
We performed a total colonoscopy for 2 healthy volunteers and a sigmoidoscopy for 15 patients with colorectal lesions by using both LED and conventional colonoscopes. We assessed the feasibility and safety of the LED colonoscope by using a 5-grade scale. The 30 images of 15 colorectal lesions obtained by using each endoscope were evaluated in a blind, randomized order by 2 endoscopists.
Main Outcome Measurements:
The mean scores of the LED colonoscope for the operability, ease of manipulation, image quality, and safety.
Results:
We manufactured a prototype LED colonoscope with white LEDs on its tip. The LED colonoscope did not require an external light source or light-guide fiber bundle. The operability and ease of manipulation of the LED colonoscope were evaluated as similar to those of the conventional colonoscope. The color of the colonic mucosa and the vascular pattern were clearly visualized in the volunteers. For the 15 colorectal lesions, the mean score for image quality was not significantly different between the colonoscopes. The study was performed safely without any incident.
Limitations:
Single-center, small number of patients.
Conclusions:
The use of an LED colonoscope is feasible, and LED illumination may simplify the endoscope system.
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