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Updated: Jun 4, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Targets for preventing epilepsy following cortical injury
Huifang Li1, Whitney McDonald, Isabel Parada
1Epilepsy Research Laboratory, Department of Neurology and Neurological Sciences, Stanford University Sch. of Medicine, 300 Pasteur Dr., Stanford, CA 94305, United States.
None:
Prophylaxis of posttraumatic epilepsy will require a detailed knowledge of the epileptogenic pathophysiological processes that follow brain injury. Results from studies of experimental models and human epilepsy highlight alterations in GABAergic interneurons and formation of excessive new excitatory synaptic connectivity as prominent targets for prophylactic therapies. Promising laboratory results suggest that it will be possible to experimentally modify these aberrant processes and interfere with epileptogenesis. However, a number of key issues must be addressed before these results can be used to frame clinical antiepileptogenic therapy.
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