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Obsessive-Compulsive Disorder

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...

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Related Experiment Video

Updated: Jun 4, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

EEG source analysis in obsessive-compulsive disorder.

Jana Kopřivová¹, Marco Congedo, Jiří Horáček

¹Prague Psychiatric Centre, Prague, Czech Republic. koprivova@pcp.lf3.cuni.cz

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology

|March 1, 2011

Summary

This summary is machine-generated.

Obsessive-compulsive disorder (OCD) patients show abnormal brain activity in the medial frontal cortex. This study used electroencephalography (EEG) to reveal hyperactivation in OCD, offering potential diagnostic and therapeutic insights.

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Last Updated: Jun 4, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

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Published on: March 14, 2025

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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

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Published on: January 9, 2015

Area of Science:

Neuroscience
Psychiatry
Medical Imaging

Background:

Obsessive-compulsive disorder (OCD) is a debilitating mental health condition.
Understanding the neurobiological underpinnings of OCD is crucial for developing effective treatments.

Purpose of the Study:

To investigate intracortical electroencephalography (EEG) source activity in patients with OCD.
To compare EEG source localization between OCD patients and healthy controls.

Main Methods:

Utilized resting-state EEG data from 50 OCD patients and 50 matched controls.
Employed standardized low-resolution electromagnetic tomography (sLORETA) and normative independent component analysis (NICA).
Analyzed data with 1 Hz frequency resolution and group independent component analysis (ICA).

Main Results:

sLORETA identified a low-frequency power excess (2-6 Hz) in the medial frontal cortex of OCD patients.
NICA revealed increased low-frequency power in a component associated with subgenual anterior cingulate, limbic, and lateral frontal cortex activity.
Both methods consistently indicated medial frontal hyperactivation in OCD.

Conclusions:

EEG source localization methods confirm medial frontal hyperactivation in OCD.
Normative ICA shows promise as a diagnostic tool for clinical samples.
Findings support EEG-based diagnostic approaches and therapeutic interventions for OCD.