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The relationship between renal functions and thrombolysis in myocardial infarction frame count in patients with slow
Fatih Koc1, Nihat Kalay, Hakan Kilci
1Department of Cardiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey. drfatkoc@gmail.com
Insights
Patients with slow coronary flow (SCF) exhibit impaired renal function. This study found a negative correlation between glomerular filtration rate (GFR) and coronary thrombolysis in myocardial infarction frame count (TFC), indicating worse kidney function in SCF patients.
Area of Science:
- Cardiology
- Nephrology
- Medical Diagnostics
Background:
- Slow coronary flow (SCF) is a condition affecting coronary artery blood flow.
- The relationship between SCF and renal function requires further investigation.
Purpose of the Study:
- To investigate the association between renal function and slow coronary flow (SCF).
- To compare renal function parameters in patients with and without SCF.
Main Methods:
- Utilized thrombolysis in myocardial infarction frame count (TFC) to assess coronary flow.
- Calculated glomerular filtration rate (GFR) and corrected GFR (cGFR) using the Cockcroft-Gault formula.
- Compared renal function markers (blood urea nitrogen, creatinine, GFR, cGFR) between SCF patients and controls.
Main Results:
- Patients with SCF had significantly higher blood urea nitrogen and creatinine levels.
- GFR and cGFR were significantly lower in the SCF group compared to the control group.
- A negative correlation was observed between GFR/cGFR and TFC.
Conclusions:
- Impaired renal function is associated with slow coronary flow.
- Patients diagnosed with SCF demonstrate poorer renal function compared to those without SCF.
Abstract:
We investigated the relationship between renal function and coronary thrombolysis in myocardial infarction frame count (TFC) in patients with slow coronary flow (SCF). The patient group was composed of 34 patients with SCF. The control group was made up of 34 well-matched individuals who have normal SCF in their coronary arteries. The coronary flow rates of all subjects were documented by TFC. Glomerular filtration rate (GFR) and corrected GFR (cGFR) were calculated by creatinine clearance according to the Cockcroft-Gault formula. There is no difference in the gender or age of the groups. Blood urea nitrogen and creatinine were significantly higher in the SCF group compared the control group (blood urea nitrogen: 17 ± 6 mg/dL vs. 14 ± 4 mg/dL, p=0.04 and creatine: 0.9 ± 0.1mg/dL vs. 0.7 ± 0.1mg/dL, p=0.01). GFR and cGFR were significantly different between the groups (GFR: 92 ± 28 mL/min vs. 112 ± 27 mL/min, p=0.004 and cGFR: 77 ± 22 mL/min/1.73 m(2)vs. 96 ± 24 mL/min/1.73 m(2), p=0.007). There was a negative correlation between GFR/cGFR and TFC in all coronary arteries. This study shows that impaired renal function is associated with SCF. Patients with SCF have worse renal function compared with patients without SCF.
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