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Luana Perioli1, Valeria Ambrogi, Cinzia Pagano

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New vaginal tablets using hydroxypropyl methylcellulose (HPMC) enhance benzydamine delivery. These mucoadhesive formulations offer improved anti-inflammatory and antiseptic effects through prolonged drug release.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems

Background:

  • Benzydamine possesses anti-inflammatory and antiseptic properties.
  • Current vaginal formulations may have limitations in efficacy and patient comfort.

Purpose of the Study:

  • To develop novel vaginal tablet formulations of benzydamine.
  • To enhance the pharmacological effect of benzydamine through improved drug delivery.

Main Methods:

  • Formulation of benzydamine in solid dispersions using mucoadhesive polymers (HPMC and Carbopol®).
  • Characterization of tablets including friability, hardness, hydration, DSC, mucoadhesion, and in vitro release studies.
  • Investigation of drug release kinetics.

Main Results:

  • Tablets formulated with HPMC exhibited superior swelling and mucoadhesion (time and force).
  • HPMC tablets demonstrated prolonged and complete drug release via a diffusive mechanism through a gelled layer.
  • Carbopol® formulations resulted in a non-homogeneous, brittle gel, leading to inconsistent drug release.

Conclusions:

  • Hydroxypropyl methylcellulose (HPMC) mucoadhesive tablets are a suitable delivery system for benzydamine.
  • These formulations offer a promising alternative to traditional vaginal dosage forms for topical therapy.
  • The developed HPMC system ensures effective and comfortable benzydamine administration.