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[Study on the alkaloids in the stems and leaves of Stephania cepharantha (II)]
Li He1, Yuan-Hu Zhang, Li-Jia Tang
1The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China. heli5179@163.com
Objective:
To study the alkaloids in the stems and leaves of Stephania cepharantha Hayata.
Methods:
The dried stems and leaves of Stephania cepharantha Hayata were percolated with 95% ethanol and the solvent was removed by rotary evaporation to give a concentrate, and the concentrate was extracted by petroleum ether and chloroform. Column chromatograghy on MCI CHP 20P, silica gel, Rp-18, Sephadex LH-20 and polyamide were applied for the isolation and purification of the chloroform fraction. The structures were elucidated by their physicochemical properties and spectral data.
Results:
Five alkaloids were obtained and identified as, Stephasunoline (I) Aknadinine (II), Discretamine (III), Acutumine (IV), Sinomenine (V).
Conclusion:
Compounds I, III, IV are isolated from this plant for the first time, and compound IV is isolated from the genus for the first time.
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