Related Experiment Videos
[Study on pharmacokinetics of phillyrin in Shuanghuanglian for injection]
Fan-Lin Zeng1, Zhi-Bin Shen, Xin Zhang
1School of Traditional Chinese Medicine of Guangdong Pharmaceutical University, Guangzhou 510006, China. zengfanlin-honglan@126.com
Objective:
To study the plasma concentration and pharmacokinetics of phillyrin in Shuanghuanglian for injection in rats.
Methods:
SD rats were given Shuanghuanglian for injection by iv, blood samples were collected at different time. The phillyrin concentration in plasma was determined by RP-HPLC. The parameters of pharmacokinetics were analyzed by program DAS 2.0.
Results:
The main pharmacokinetics parameters of phillyrin in rats:t1/2 (alpha) (0.44 +/- 0.06) h, t1/2 (beta) (2.77 +/- 0.36) h, V1 (0.09 +/- 0.01) L/kg, CL (0.09 +/- 0.007) L/(h x kg), AUC0-1, (5.56 +/- 0.47 mg x h/L), AUC0-infinity (6.44 +/- 0.53) mg x h/L.
Conclusion:
Phillyrin has two compartment model in rats, the pharmacokinetics of phillyrin characteristic is a process of rapid dispatching and slow elimination in rats.
Related Concept Videos
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Bioavailability Study Design: Single Versus Multiple Dose Studies
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Biopharmaceutics and Pharmacokinetics: Overview
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Measurement of Bioavailability: Pharmacokinetic Methods