[Influence of suoquan capsule on detrusor of D-galactose mimetic rats]
Related Experiment Video
Updated: Jan 6, 2026
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Ying Tan1, Ping Huang, Hongying Cao
1Yunnan Institute of Materia Medica, Kunming 650111, China. ty1203@163.com
Objective:
To discuss the influence of Suoquan capsule (SQJN) on the detrusor of D-galactose mimetic rats, and to explore the mechanism of reducing urine.
Method:
Investigate the enzymes (ATPase, SDH, SOD, MDA, Na+ -K+ -ATPase, Ca2+ - Mg2+ -ATPase) which influence the production and excretion of urine and the reactivity of urinary detrusor strips to different concentrations of ISO and ATP.
Result:
Compared with the model group, the activity of SOD, Na+ -K+ -ATPase, Ca2+ -Mg2+ -ATPase and SDH increased significantly in aging rats after administrating SQJN (P < 0.01); the complaisance and elasticity of bladder also increased (P < 0.05). The frequency of spontaneous contraction and the MDA decreased significantly (P < 0.05-0.01). The decreased relaxation response to ISO and increased contractile response to ATP were also changed after administrating SQJN.
Conclusion:
SQJN can regulate the metabolism of fluid through recovering the normal physiologic function of the detrusor of bladder.
