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Palladium-catalyzed oxidative sp2 C-H bond acylation with alcohols
Fuhong Xiao1, Qi Shuai, Feng Zhao
1Key Laboratory for Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, China.
Abstract:
An efficient method was developed for the direct acylation of arene sp(2) C-H bonds with alcohols using palladium chloride as a catalyst and peroxide as the oxidant. The alcohols were oxidized to their corresponding aldehydes in situ and efficiently coupled with 2-arylpyridines to give aryl ketones in chlorobenzene.
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