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Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

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Treating acne with antibiotic-resistant bacterial colonization.

Thrasivoulos Tzellos¹, Vasiliki Zampeli, Evgenia Makrantonaki

¹Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg Dessau, Germany. christos.zouboulis@klinikum-dessau.de

Expert Opinion on Pharmacotherapy

|March 2, 2011

Summary

Antibiotic-resistant acne is a growing concern. Strategies to combat this include rational prescribing, combination therapies, and non-antibiotic agents, with benzoyl peroxide being a key treatment.

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Area of Science:

Dermatology
Microbiology
Pharmacology

Background:

Acne vulgaris is a common pilosebaceous unit disorder with complex pathogenesis.
Propionibacterium acnes is implicated in acne inflammation, with antibiotics historically being the primary treatment.
Increasing prevalence of antibiotic-resistant Propionibacterium acnes strains poses a therapeutic challenge.

Purpose of the Study:

To review the pathophysiology of antibiotic-resistant acne.
To explore strategies for minimizing antibiotic resistance development in acne treatment.
To discuss approaches for managing antibiotic-resistant acne.

Main Methods:

Literature review up to August 2010.
Search terms included 'acne', 'antibiotic-resistant acne', and 'bacterial resistance'.
Focus on pathophysiology and management strategies.

Main Results:

Antibiotic resistance in acne is a significant clinical issue.
Effective management requires a multi-faceted approach beyond traditional antibiotic use.
Evidence supports benzoyl peroxide and oral isotretinoin for specific acne severities.

Conclusions:

Antibiotic-resistant acne necessitates comprehensive management strategies.
Rational prescribing, combination therapies, and non-antibiotic agents are crucial.
Benzoyl peroxide demonstrates strong evidence, while oral isotretinoin is effective for severe cases.