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Treating acne with antibiotic-resistant bacterial colonization

Thrasivoulos Tzellos1, Vasiliki Zampeli, Evgenia Makrantonaki

  • 1Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg Dessau, Germany. christos.zouboulis@klinikum-dessau.de

Expert Opinion on Pharmacotherapy
|March 2, 2011
PubMed
Abstract

Insights

Antibiotic-resistant acne is a growing concern. Strategies to combat this include rational prescribing, combination therapies, and non-antibiotic agents, with benzoyl peroxide being a key treatment.

Area of Science:

  • Dermatology
  • Microbiology
  • Pharmacology

Background:

  • Acne vulgaris is a common pilosebaceous unit disorder with complex pathogenesis.
  • Propionibacterium acnes is implicated in acne inflammation, with antibiotics historically being the primary treatment.
  • Increasing prevalence of antibiotic-resistant Propionibacterium acnes strains poses a therapeutic challenge.

Purpose of the Study:

  • To review the pathophysiology of antibiotic-resistant acne.
  • To explore strategies for minimizing antibiotic resistance development in acne treatment.
  • To discuss approaches for managing antibiotic-resistant acne.

Main Methods:

  • Literature review up to August 2010.
  • Search terms included 'acne', 'antibiotic-resistant acne', and 'bacterial resistance'.
  • Focus on pathophysiology and management strategies.

Main Results:

  • Antibiotic resistance in acne is a significant clinical issue.
  • Effective management requires a multi-faceted approach beyond traditional antibiotic use.
  • Evidence supports benzoyl peroxide and oral isotretinoin for specific acne severities.

Conclusions:

  • Antibiotic-resistant acne necessitates comprehensive management strategies.
  • Rational prescribing, combination therapies, and non-antibiotic agents are crucial.
  • Benzoyl peroxide demonstrates strong evidence, while oral isotretinoin is effective for severe cases.

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