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Texaphyrins: tumor localizing redox active expanded porphyrins
Jonathan F Arambula1, Christian Preihs, Derric Borthwick
1Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712-0165, USA.
Abstract:
Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimental use in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.
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