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Published on: April 11, 2018

Primary cardiac synovial sarcoma: a case report and literature review

Yuki Yokouchi1, Nobuyuki Hiruta, Toshiaki Oharaseki

  • 1Department of Surgical Pathology Cardiovascular Medicine Cardiovascular Surgery Radiology, Toho University Ohashi Medical Center, Tokyo, Japan. tyuki@med.toho-u.ac.jp

Pathology International
|March 2, 2011
PubMed

Insights

Primary cardiac synovial sarcoma, a rare cancer, was diagnosed in a 51-year-old man presenting with exercise-induced palpitations. Surgical resection and radiation therapy led to no recurrence at 9 months.

Area of Science:

  • Cardiovascular Pathology
  • Surgical Oncology
  • Molecular Diagnostics

Background:

  • Primary cardiac tumors are rare, with synovial sarcoma being an exceptionally uncommon diagnosis.
  • Early detection and accurate diagnosis are crucial for effective management of cardiac malignancies.

Observation:

  • A 51-year-old male presented with palpitations and dyspnea on exertion.
  • Imaging revealed significant bloody pericardial effusion and an intrapericardial tumor.
  • Histopathological examination showed spindle-shaped cells, myxoid changes, and a hemangiopericytoma-like vascular pattern.

Findings:

  • Immunohistochemistry and SS18-SSX1 fusion transcript detection confirmed a diagnosis of monophasic fibrous type synovial sarcoma.
  • Surgical resection of the intrapericardial tumor was successfully performed.
  • Postoperative radiation therapy was administered to the patient.

Implications:

  • This case highlights the importance of considering rare diagnoses like primary cardiac synovial sarcoma in patients with cardiac symptoms.
  • Successful surgical and adjuvant treatment strategies can lead to favorable outcomes.
  • Further research into cardiac sarcomas may improve diagnostic and therapeutic approaches.

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