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Related Concept Videos

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
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The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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Tooth Anatomy01:21

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Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors01:13

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Related Experiment Video

Updated: Jun 4, 2026

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
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Published on: December 26, 2016

Can anti-erosion dentifrices also provide effective plaque control?

P G Bellamy1, M Prendergast, R Strand

  • 1Procter & Gamble, London Innovation Centre, Egham, Surrey, UK. bellamy.pg@pg.com

International Journal of Dental Hygiene
|March 2, 2011
PubMed
Summary

A new stannous chloride/sodium fluoride (SnCl(2)/NaF) toothpaste significantly reduced plaque levels compared to a sodium fluoride (NaF) toothpaste. This anti-erosion dentifrice offers superior plaque inhibition for better oral hygiene.

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Area of Science:

  • Oral hygiene research
  • Dental caries and erosion prevention
  • Periodontal disease management

Background:

  • Gingivitis and caries are prevalent dental issues.
  • Increasing concern exists regarding dental erosion from dietary acids.
  • A need for oral hygiene products addressing multiple dental conditions is recognized.

Purpose of the Study:

  • To investigate the plaque-inhibiting potential of two anti-erosion dentifrices.
  • To compare a stannous chloride/sodium fluoride (SnCl(2)/NaF) dentifrice against a sodium fluoride (NaF) dentifrice.
  • To evaluate the efficacy of these dentifrices in reducing plaque levels.

Main Methods:

  • A randomized, double-blind, crossover study design was employed.
  • Participants used either a SnCl(2)/NaF or NaF dentifrice for 17-day periods.
  • Digital plaque image analysis (DPIA) assessed plaque at overnight, post-brushing, and mid-afternoon intervals.

Main Results:

  • The SnCl(2)/NaF dentifrice demonstrated statistically significant plaque reduction at all measured time points (P ≤ 0.0001).
  • Compared to NaF, SnCl(2)/NaF provided a 26.0% reduction in overnight plaque, 27.9% post-brushing, and 25.7% mid-afternoon.
  • Twenty-seven subjects completed the study, confirming consistent results.

Conclusions:

  • The SnCl(2)/NaF dentifrice significantly inhibited plaque formation more effectively than the NaF toothpaste.
  • Clinicians can consider SnCl(2)/NaF dentifrices for patients at risk of dental erosion who also require plaque control.
  • This study highlights the dual benefit of anti-erosion dentifrices in managing plaque accumulation.