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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
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Non-coding RNAs enter mitosis: functions, conservation and implications.

Jun Wei Pek1, Toshie Kai

  • 1Department of Biological Sciences and Temasek Life Sciences Laboratory, 1 Research Link, The National University of Singapore, 117604, Singapore. junwei@tll.org.sg.

Cell Division
|March 2, 2011
PubMed
Summary
This summary is machine-generated.

Nuage, a germline organelle, plays a key role in chromosome condensation and segregation during mitosis. This function is linked to the piRNA pathway, suggesting novel roles beyond genome defense.

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Last Updated: Jun 4, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
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Published on: August 21, 2014

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11:09

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Area of Science:

  • Reproductive Biology
  • Cell Biology
  • Genetics

Background:

  • Nuage (chromatoid body in mammals) is a germline-specific organelle associated with the Piwi-interacting RNA (piRNA) pathway.
  • piRNAs are crucial for genome stability by silencing retrotransposons and have emerging roles in development and telomere protection.
  • The piRNA pathway is conserved across species and plays vital roles in germline integrity.

Discussion:

  • Vasa, a nuage component, facilitates chromosome condensation and segregation by ensuring proper localization of condensin I during mitosis in Drosophila germline.
  • Vasa's mitotic role involves interactions with Aubergine and Spindle-E/mouse TDRD-9, linking the piRNA pathway to mitotic chromosome dynamics.
  • This research proposes models for Vasa and piRNA pathway involvement in mitosis.

Key Insights:

  • Vasa protein is essential for accurate chromosome condensation and segregation in the Drosophila germline.
  • A direct link is established between the piRNA pathway and the regulation of mitosis.
  • Nuage components have functions extending to cell division processes.

Outlook:

  • Further investigation into the proposed models for Vasa and piRNA pathway functions during mitosis is warranted.
  • Exploring the broader implications of RNA and nuage involvement in mitosis across different model systems.
  • Understanding these mechanisms may offer insights into cancer development, particularly concerning genome stability and cell division errors.