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Related Experiment Video

Updated: Jun 4, 2026

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

Differences in breast tissue oxygenation following radiotherapy.

Ken Dornfeld1, Charles E Gessert, Colleen M Renier

  • 1Department of Radiation Oncology, St. Mary's Duluth Clinic Health System, USA. kdornfeld@smdc.org

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|March 2, 2011
PubMed
Summary

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Radiotherapy can alter breast tissue oxygenation. One year post-treatment, non-diabetic patients showed lower oxygen levels in the irradiated breast compared to the control breast, suggesting varied tissue responses.

Area of Science:

  • Oncology
  • Medical Physics
  • Radiotherapy Research

Background:

  • Radiotherapy can induce changes in tissue perfusion and oxygenation.
  • These changes may influence treatment toxicity and long-term outcomes.
  • Understanding post-radiotherapy tissue oxygenation is crucial for managing side effects.

Purpose of the Study:

  • To assess breast tissue oxygenation levels one year after radiotherapy for breast-conserving treatment.
  • To compare oxygenation in irradiated versus non-irradiated breast tissue.
  • To investigate the influence of diabetes mellitus on post-radiotherapy oxygenation patterns.

Main Methods:

  • Transcutaneous oxygenation measurements were performed on both treated and control breasts.
  • Participants included patients treated with breast-conserving therapy.

Related Experiment Videos

Last Updated: Jun 4, 2026

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

  • Subjects were stratified based on diabetes mellitus status.

    • Main Results:

    • Significant inter-subject variability in oxygenation was observed in both breasts.
    • Non-diabetic patients (n=16) exhibited lower average oxygenation in the irradiated breast (64.8 ± 19.9 mmHg) versus the control breast (72.3 ± 18.1 mmHg, p=0.018).
    • Diabetic patients (n=4) displayed distinct patterns, with lower control tissue oxygenation and no decrease in the irradiated breast.

    Conclusions:

    • Breast tissue oxygenation levels exhibit significant inter-patient variability after radiotherapy.
    • Diabetes mellitus may alter the response of breast tissue oxygenation to radiotherapy.
    • These findings suggest personalized approaches may be needed to manage radiotherapy-induced tissue changes.