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The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: Jun 4, 2026

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Published on: September 20, 2016

A novel approach to assessing changes in prostate stiffness with age using virtual touch tissue quantification.

Xiao-Zhi Zheng¹, Ping Ji, Hong-Wei Mao

¹Department of Ultrasound, Fourth Affiliated Hospital of Nantong University, First People's Hospital of Yancheng, Yancheng, China. zxzycyy1232@126.com

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine

|March 2, 2011

Summary

Virtual touch tissue quantification accurately measures prostate stiffness. This ultrasound technique reveals significant age-related increases in shear wave velocity, indicating prostate aging.

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Last Updated: Jun 4, 2026

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

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A Probing Device for Quantitatively Measuring the Mechanical Properties of Soft Tissues during Arthroscopy

A Probing Device for Quantitatively Measuring the Mechanical Properties of Soft Tissues during Arthroscopy

Published on: May 1, 2020

Area of Science:

Medical imaging
Ultrasound elastography
Prostate diagnostics

Background:

Virtual touch tissue quantification (VTQ) is an advanced acoustic radiation force impulse (ARFI) ultrasound technique.
VTQ offers a non-invasive method for assessing tissue stiffness.
Understanding normal prostate stiffness and its age-related changes is crucial for clinical evaluation.

Purpose of the Study:

To establish normal shear wave velocity (SWV) values for the prostate using VTQ.
To evaluate the clinical utility of VTQ in assessing age-related alterations in prostate stiffness.
To correlate prostate SWV with participant age.

Main Methods:

120 healthy volunteers were stratified into three age groups: young (<30), middle-aged (30-60), and old (>60).
Shear wave velocity (SWV) was measured in the inner and outer prostate glands using VTQ at a depth of approximately 5.5 cm.
Statistical analysis was performed to compare SWV across age groups and correlate it with age.

Main Results:

Mean SWV increased significantly with age in both inner and outer prostate glands.
The old group exhibited significantly higher SWV compared to young and middle-aged groups (P < .05).
SWV showed a significant positive correlation with age in all measurements.

Conclusions:

VTQ provides objective, quantitative measurements of prostate stiffness.
VTQ effectively detects and quantifies age-related changes in prostate stiffness through SWV assessment.
This technique holds promise for non-invasively monitoring prostate aging.