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12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Naproxen-induced fixed drug eruption: a case report.
Hikmet Akyazi1, Davut Baltaci, Sevdegul Mungan
1Department of Family Medicine, Medical Faculty, Duzce University, Duzce, Turkey.
Human & Experimental Toxicology
|March 2, 2011
Summary
Naproxen can rarely cause fixed drug eruption (FDE), a skin reaction. This case study shows no cross-reactivity with other propionic acid derivatives like flurbiprofen.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Naproxen, a common NSAID, is used for pain and inflammation.
- Pruritus is its most frequent side effect.
- Fixed drug eruption (FDE) is a rare adverse reaction to naproxen.
Observation:
- A 28-year-old man developed acute lip lesions after taking naproxen.
- Symptoms recurred upon subsequent naproxen exposure.
- Clinical and histopathological examination confirmed naproxen-induced FDE.
Findings:
- This case highlights naproxen-induced FDE.
- Cross-reactivity testing with flurbiprofen via oral provocation yielded negative results.
- No prior reports documented cross-reactivity between naproxen and propionic acid derivatives.
Implications:
- This case expands the understanding of naproxen's adverse effects.
- The negative cross-reactivity suggests potential alternative NSAID options for patients with naproxen-induced FDE.
- Further research into NSAID cross-reactivity is warranted.
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