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Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
The Extracellular Matrix01:42

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.

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Related Experiment Video

Updated: Jun 4, 2026

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
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Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography

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[Matrix metalloproteinases and atherosclerosis].

Piotr Fic1, Izabela Zakrocka, Jacek Kurzepa

  • 1Oddział Kardiologii z Pododdziałem Kardiologii Inwazyjnej, Specjalistyczny Szpital Wojewódzki im. Kardynała Stefana Wyszyńskiego w Lublinie.

Postepy Higieny I Medycyny Doswiadczalnej (Online)
|March 2, 2011
PubMed
Summary

Matrix metalloproteinases (MMPs) play a key role in atherosclerosis development and plaque rupture. Targeting MMPs may offer new therapeutic strategies for cardiovascular disease.

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Published on: March 30, 2022

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Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels
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Area of Science:

  • Biochemistry
  • Cardiovascular Biology
  • Molecular Medicine

Context:

  • Atherosclerosis involves complex molecular processes, including extracellular matrix (ECM) degradation.
  • Matrix metalloproteinases (MMPs), ECM-degrading enzymes, are implicated in vascular remodeling.
  • Inflammatory cells and smooth muscle cells release MMPs, influencing atherosclerotic plaque development.

Purpose:

  • To explore the role of MMPs in the pathogenesis of atherosclerosis.
  • To discuss the regulation of MMP expression and activity.
  • To evaluate the potential of MMP inhibitors as a therapeutic strategy for atherosclerosis.

Summary:

  • MMPs are proteolytic enzymes crucial for ECM turnover and vascular remodeling.
  • Dysregulated MMP activity, often due to overproduction, contributes to atherosclerotic plaque formation and rupture.
  • Elevated MMP levels in plasma are potential biomarkers for cardiovascular risk.
  • MMP inhibitors are being investigated for their therapeutic potential in treating atherosclerosis.

Impact:

  • Understanding MMPs' role enhances our knowledge of atherosclerosis pathogenesis.
  • Increased plasma MMP levels may serve as early indicators of cardiovascular risk.
  • MMP inhibitors represent a promising avenue for novel atherosclerosis therapies.
  • This research could lead to improved clinical outcomes for patients with cardiovascular disease.